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  • 绀句細瀹炶返> 椤圭洰鍒嗙被> 绉戝垱鐮旂┒闄㈣繙绋嬬鐮斿疄涔犺惀锛氱敓鐗╁尰瀛︽柟鍚?/a>

    椤圭洰鍦扮偣锛?/p> 鍖椾含

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    椤圭洰璐圭敤锛?/p> 鐐瑰嚮鍜ㄨ>>

    銆€銆€涓€銆侀」鐩畝浠?/strong>

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    銆€銆€浜屻€侀」鐩唴瀹?/strong>

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    銆€銆€浜嗚В缁嗚優绋嬪簭鎬ф浜$殑鐮旂┒鍘嗙▼锛岀爺绌舵€濊矾浠ュ強鐢熺墿鍖栧鐨勮瘯楠屾柟娉曞湪鐢熺墿鍖诲鐮旂┒涓殑搴旂敤锛?/p>

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    銆€銆€浜嗚В缁嗚優鑷櫖鐨勭爺绌跺巻绋嬶紝鐮旂┒鎬濊矾浠ュ強閬椾紶瀛︾殑瀹為獙鏂规硶鍦ㄧ敓鐗╁尰瀛︾爺绌朵腑鐨勫簲鐢ㄣ€?/p>

    銆€銆€涓夈€佸笀璧勫姏閲?/strong>

    銆€銆€浠昏亴鏁欏笀涓哄寳浜敓鍛界瀛︾爺绌舵墍鍗氬+鍚庣爺绌跺憳銆傛浘灏辫浜庢竻鍗庡ぇ瀛?鍖椾含鐢熷懡绉戝鐮旂┒鎵€锛岃幏寰楃敓鐗╁鍗氬+銆傚崥澹湡闂村湪siRNA/Ago 4澶嶅悎鐗╁湪鎷熷崡鑺ョ粏鑳炶川涓庣粏鑳炴牳涓浆杩愭満鍒躲€佺粏鑳炲噵浜′笌鍧忔灏忓垎瀛愭姂鍒跺墏鍜岀粏鑳炶嚜鍣湪妯″紡鐢熺墿绾胯櫕绛夊涓鍩熷紑灞曠爺绌讹紝寰楀埌浜嗗浗瀹堕噸鐐瑰熀纭€鐮旂┒鍙戝睍璁″垝椤圭洰(973璁″垝)銆佸浗瀹惰嚜鐒剁瀛﹀熀閲戙€佸浗瀹剁鎶€閲嶅ぇ涓撻」绛夊椤瑰浗瀹堕噸鐐硅棰樼爺绌惰鍒掔殑鏀寔銆?017骞村紑濮嬪湪鍖椾含鐢熷懡绉戝鐮旂┒鎵€璐熻矗涔欏瀷鑲濈値鐥呮瘨(HBV)鍜屼竵鍨嬭倽鐐庣梾姣?HDV)涓拰鎶椾綋鐨勭浉鍏崇爺绌躲€傝鏂囧彂琛ㄥ湪Elife(涓闄CR鍒嗗尯1鍖?绛夐噸瑕佸鏈湡鍒婁笂锛屽苟鑾峰緱鍥介檯涓撳埄銆?/p>

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    銆€銆€浜斻€佽绋嬪畨鎺?/strong>

    銆€銆€杩滅▼绉戠爺鎸囧椤圭洰鏃堕暱涓€涓湀锛屽叿浣撲笂璇炬椂闂村彲鏍规嵁瀛︾敓闇€姹備互鍙婂悎閫傜殑鏃堕棿杩涜瀹夋帓锛屽叿鏈夊緢澶х殑鐏垫椿鎬с€?瀵煎笀鍙互甯姪瀛︾敓鏇村姞娣卞叆銆佹洿鍔犲叏闈€佹洿鍔犵郴缁熷湴瀹屾垚涓€椤瑰畬鏁寸殑涓撲笟棰嗗煙绉戠爺浠诲姟锛岃瀛︾敓浜茶韩鍙備笌鍒版暣涓鐮旈」鐩紑灞曠殑杩囩▼锛?浣撻獙绉戠爺鐨勫熀鏈祦绋嬶紝鎰熷彈绉戠爺鐨勯瓍鍔涳紝鍚屾椂鍙互璁╁鐢熶簡瑙e埌璇ラ鍩熻儗鏅強鍓嶆部鍔ㄦ€佺瓑銆傞櫎浜嗗畾鏈熺鐮旈」鐩璁鸿绋嬩箣澶栵紝椤圭洰鍛ㄦ湡鍐呭鐢熷彲浠ラ殢鏃跺悜瀵煎笀璇锋暀鐩稿叧闂锛屽緱鍒板甯堢殑涓撲笟鎸囧锛?纭珛鑷繁鏈潵鐨勫彲鑳界殑鐮旂┒鏂瑰悜涓庣爺绌惰鍒掋€?span style="text-indent: 48px; font-family: dengxian">鍏蜂綋璇剧▼瀹夋帓濡備笅锛?/font>

    璇炬椂

    鍐呭

    鐩稿叧璁烘枃

    绗竴璁?/span>

    1. 浜嗚В绋嬪簭鎬х粏鑳炴浜$殑鐮旂┒鍘嗗彶

    2. 浜嗚В缁忓吀鐨勭敓鐗╁寲瀛︾函鍖栨柟娉曞湪鐢熺墿鐮旂┒涓殑搴旂敤

    3. 浜嗚В鎬庝箞鏇村ソ鐨勭悊瑙f湁鍏崇粏鑳炴浜$殑鏂囩珷

    Xuesong Liu-1996-Cell-Induction of Apoptotic Program in Cell-Free Extracts- Requirement for dATP and Cytochrome c

    绗簩璁?/span>

    1. 浜嗚В娌荤枟鎬ф姉浣撶殑鐮旂┒鍜屽彂灞曞巻鍙?/span>

    2. 浜嗚В缁忓吀鐨勪复搴婁笂鐨勬不鐤楁€ф姉浣撶殑鍙戝睍

    3. 浜嗚В鎬庝箞鏇村ソ鐨勭悊瑙f湁鍏虫不鐤楁€ф姉浣撶殑鏂囩珷

    Andrew-2012-Nature review-Antibody therapy of cancer

    绗笁璁?/span>

    1. 浜嗚ВHBV鍙椾綋鐨勫彂鐜版晠浜?/span>

    2. 浜嗚В鍙椾綋鍙互浣滀负闈剁偣寮€鍙?/span>HBV娌荤枟鎬ц嵂鐗?/span>

    3. 浜嗚В鎬庝箞鏇村ソ鐨勭悊瑙f湁鍏?/span>HBV 鎰熸煋鐨勬枃绔?/span>

    Huan Yan-Elife-2012-Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

    绗洓璁?/span>

    1. 浜嗚В缁嗚優鑷櫖鐨勭爺绌跺巻鍙?/span>

    2. 浜嗚В缁忓吀鐨勯仐浼犳柟娉曞湪鐢熺墿鐮旂┒涓殑搴旂敤

    3. 浜嗚В鎬庝箞鏇村ソ鐨勭悊瑙f湁鍏崇粏鑳炶嚜鍣殑鏂囩珷

    Tian Ye-2010-Cell-C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms

    绗簲璁?/span>

    1. 浜嗚В鐢熺墿瀹為獙瀹ょ殑鍩烘湰鏋勬垚

    2. 浜嗚В濡備綍鍑嗗鍩烘湰鐨勭敓鐗╁瀹為獙

    3. 浜嗚В铔嬬櫧鍒嗙鑳剁殑鍩烘湰瀹為獙鎿嶄綔

     

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